Investigation of the pathogenesis of vascular leak in dengue
Vascular leak is the hallmark of severe dengue. Our laboratory has identified several key mediated that cause vascular leak including platelet activating factor (PAF) and sphingosine-1-phosphate (S1P). We are currently trying to understand the factors that lead to generation of PAF in severe dengue.
The role of NS1 antibodies in dengue
Dengue NS1 is a secretory protein of the dengue virus, which exists in the hexameric form, with a lipid rich core. It was found to induce inflammatory cytokine production from mononuclear cells and also contribute to vascular leak. NS1 antigen-antibody complexes have shown to activate complement leading to severe clinical disease. Our laboratory is trying to further understand the role of NS1 antibodies in disease pathogenesis, including their qualitative and quantitative differences.
The functionality and phenotype of T cells in acute dengue
Although cross reactive T cells are believed to contribute to severe disease by producing proinflammatory cytokines, most recent studies should that dengue specific T cells might actually be playing a protective role. As this debate whether T cells are protective or not continues, our laboratory is investigating the functionality and phenotype of dengue specific T cells in patients with varying severity of acute dengue.
Differences in the innate immune responses to the dengue virus in those who develop severe and non-severe dengue.
Clinical trial on efficacy of rupatadine for the treatment of acute dengue