Publications and research on dengue infection

Publications in high impact international journals

  1. Pathogenesis of vascular leak in dengue virus infection. Immunology. 2017 Apr 24
  2. Secretory Phospholipase A2 in acute dengue infection. 2016.Emerging and re-emerging infectious disease threats in South Asia: status, vulnerability, preparedness, and outlook. BMJ. 2017 Apr 11;357:j1447. doi: 10.1136/bmj.j1447.
  3. Viral aetiologies of acute encephalitis in a hospital-based South Asian population. BMC Infect Dis. 2017 Apr 24;17(1):303.
  4. Mathematical Modelling of Immune Parameters in the Evolution of Severe Dengue. Comput Math Methods Med. 2017;2017:2187390. doi: 10.1155/2017/2187390.
  5. Mathematical modelling and a systems science approach to describe the role of cytokines in the evolution of severe dengue. BMC Syst Biol. 2017 Mar 11;11(1):34. doi: 10.1186/s12918-017-0415-3.
  6. Lipopolysaccharide acts synergistically with the dengue virus to induce monocyte production of platelet activating factor and other inflammatory mediators. Antiviral Res. 2016 Jul 28;133:183-190.
  7. Expansion of highly activated iNKT cells with altered phenotype in acute dengue infection. Clin Exp Immunol. 2016 Feb 13. doi: 10.1111/cei.12778
  8. Role of skin homing T cells in acute dengue infection. Annals of Translational Medicine. Ann Transl Med 2015;3(17):252. doi: 10.3978/j.issn.2305-5839.2015.09.12
  9. Dengue NS1 antigen contributes to disease severity by inducing IL-10 by monocytes. Clin Exp Immunol. 2015 Dec 1. doi: 10.1111/cei.12747
  10. Expansion of highly activated iNKT cells with altered phenotype in acute dengue infection. Clin Exp Immunol. 2016 Feb 13. doi: 10.1111/cei.12778
  11. Change in Dengue and Japanese Encephalitis Seroprevalence Rates in Sri Lanka. PLoS One. 2015 Dec 22;10 (12):e0144799. doi: 10.1371/journal.pone.0144799. eCollection 2015
  12. Sphingosine 1-phosphate in acute dengue infection. PLoS One. 2014 Nov 19;9(11):e113394. doi: 10.1371/journal.pone.0113394. eCollection 2014.
  13. Dengue NS1 antigen as a marker of severe clinical disease. BMC Infect Dis. 2014 Oct 31;14:570. doi: 10.1186/s12879-014-0570-8.
  14. T cell responses in Dengue virus infection. Journal of Clinical Virology. 2013 Oct
  15. Suppression of virus specific immune responses by IL-10 in acute dengue infection. PLOS Neglected Tropical diseases. 2013 Sep 5;7(9):e2409.

Presentations at international conferences

  1. Development and validation of an in house multiplex real time PCR for quantification of all four serotypes of dengue virus. Annual scientific sessions, University of Sri Jayewardenepura, 01-02 April 2015.
  2. Factors associated with release of platelet activating factor from dengue virus infected monocytes. European Academy of Allergy and Clinical Immunology 2015, Barcelona, Spain
  3. Interleukin I beta in the pathogenesis of dengue infection.7th Biennial scientific sessions. Allergy and Immunology society in Sri Lanka. 2nd September 2014.
  4. Mediators of Vascular leak in acute dengue infection. 127th Anniversary International Medical Congress of the SLMA.2014
  5. Suppression of virus specific immune responses by IL-10 in acute dengue infection. Presented at the European Allergy and Clinical Immunology and World Allergy Organization congress 2013
  6. Dengue and other flavi virus specific T cell specific responses in healthy individuals in Sri Lanka ,15th International Congress of Immunology; Milan, Italy ; August 2013
  7. Role of IL-10 in dengue infection. Invited lecture at the Asia Pacific Allergy and Clinical Immunology Congress 2013
  8. Defining the role of dengue virus specific T cell and antibody responses and their contribution to severe clinical disease in a large cohort of individuals from Sri Lanka –Asia Pacific Congress of Allergy, Asthma and Clinical Immunology November 14 – 17, 2013, Taiwan
  9. Role of NKT cells in the pathogenesis of dengue infection: Asia Pacific Allergy and Clinical Immunology Congress 2013
  10. Role of platelet activating factor in the pathogenesis of dengue: presented at the British Society of Immunology Congress 2013
  11. Mediators of Vascular leak in dengue infection: Invited lecture at the 16th International Congress of Infectious Diseases in Cape Town
  12. Co-stimulatory molecules in dengue infection: 16th International Congress of Infectious Diseases in Cape Town
  13. Dengue and other flavi virus specific T cell specific responses and antibody responses in past severe and non-apparent dengue viral infections in Sri Lanka: presented at the British Society of Immunology Congress 2013
  14.  Spatio-temporal distribution of dengue fever sensitivity to changing weather conditions in Colombo district-Sri Lanka: Presented at the International Conference on Health GIS. May 2013

Local

  1. Seroprevalance and serotype specific T cell responses of dengue viral infections in healthy individuals in Colombo, Sri Lanka, SLMA July 2013
  2. Usefulness of dengue NS1 antigen as a predictor of severe dengue, SLMA July 2014
  3. Mediators of Vascular leak in acute dengue infection, SLMA July 2014
  4. A novel approach to evaluate changes in micro vascular permeability and therapeutic targets in dengue infection, SLMA July 2014

Patents

International Patent: Peptide markers and uses thereof in dengue infection (publication date 14th February 2013)

Awards for research on dengue

International

  1. Best paper prize at the European Academy of Allergy, and Clinical Immunology Congress, held in Milan, June 2013
  2. Best paper prize at the Asia Pacific Allergy, Asthma and immunology congress , held in Taiwan, November, 2013
  3. Young investigator award by the American Association of Immunologists 2014: awarded to Dr. Chandima Jeewandara: PhD student CDR

Local

  1. Sri Lanka Presidential Research Awards 2014
  2. E.M. Wijerama prize for the best paper at the Sri Lanka Medical Association July, 2014
  3. CNAPT award from SLMA for the best paper published in medical science in year 2013, for the paper titled: Suppression of virus specific immune responses by IL-10 in acute dengue infection. PLOS Neglected Tropical diseases.  2013 Sep 5;7(9):e2409

Research grants received for dengue

Funding body Topic Amount
NIH, USA Investigation of the role of innate like lymphoid cells in acute dengue: Co-PI(2016-2018) US$275,000
National Science Foundation Identification of the true burden and associated complications of dengue and related viral infections in Sri Lanka and finding long lasting solutions, through in depth understanding of the pathogenesis for development of therapeutic targets 20 million for first 6 months
National Science Foundation Investigation of functionality and phenotype of T cell responses in dengue infection (2016-2018) PI LKR 6.2 million
National Science Foundation Validation of T cell based assay for determining past dengue serotype (2015-2017) PI LKR4.76 million
National Research Council Investigation of the role of dengue NS1 in the pathogenesis of dengue (2015-2018) PI LKR4.16 million
National Science Foundation Investigation of factors that lead to vascular leak in dengue. LKR 4.1 million
Sri Lanka Treasury Funds for the Centre for Dengue Research Determining correlates of a protective immune response in dengue infection. PI of this research grant. LKR 92.6 million
National Science Foundation Determining correlates of a protective immune response in dengue infection. PI LKR 5.37 million
International Society of Infectious Diseases Identification of a serum biomarker for predicting severe disease in patients with dengue infection. PI $6000
National Research Council Sri Lanka Investigation of immune responses to the dengue virus. PI LKR 1.29 million
National Science Foundation of Sri Lanka Identifying biomarkers for predicting severe disease in dengue infections. PI LKR 1.3 million
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Latest News & Events

Jan
10
Clinical trial

Clinical trial on the efficacy of rupatadine in acute dengue infection – SLCTR clinical trial number: SLCTR/2014/023

Jun
23
International workshop on dengue infections

This was held from 20th to 22nd September, 2013 at the Faculty of Medical Sciences, University of Sri Jayawardenapura.